What is major difference between squirrel vs chipmunk?

Absolutely.

It’s worth noting that chipmunks are not restricted to North America, although that’s where most of them are. There is one species, the Siberian Chipmunk (Eutamias sibiricus), that is found in Eurasia.

Where I currently work in SE Asia there are several small squirrel species in the Tamiops genus that most people would mistake for a chipmunk if they were unaware of the ranges of chipmunks vs squirrels (as most people are unaware). The little Tamiops fellows are the same size, colors, and patterns as many chipmunk species, but, like many species here, they are vastly more wary of humans than any chipmunks in North America or Eurasia I’ve encountered.